The haptoglobin genotype (hp) is linked to increased cardiovascular risk in those with diabetes, and hp variants determine whether Vitamin E therapy will increase or decrease a diabetic person’s risk for Cardiovascular Disease. The Hp gene is responsible for producing a protein that is critical in removing iron from the blood. If the extra iron is not removed, it can cause oxidative stress and inflammation in the circulatory system. This is the cause of increased risk for heart attack and stroke.